Hypercalcemia due to increased osteoclasts activity: This is one of the defining features of end-organ damage in multiple myeloma.However, in patients with multiple myeloma, there are many positively charged paraproteins, which antagonizes the negative charge on red blood cells and allows for stacking. In healthy individuals, the zeta potential of red blood cells causes intercellular repulsion. Rouleaux formation of red blood cells: This is defined as the stacking of 4 or more red blood cells.Laboratory Findings Complete blood count Some of the laboratory tests are factors that determine the stage of multiple myeloma. AG RATIO HIGH FREELaboratory findings consistent with the diagnosis of multiple myeloma include abnormal complete blood count, abnormal basic metabolic panel, elevated monoclonal protein on serum electrophoresis, elevated serum free light chains, and presence of myeloma-specific protein markers by immunohistochemistry or immunophenotyping. Associate Editor(s)-in-Chief: Hannan Javed, M.D. Risk calculators and risk factors for Multiple myeloma laboratory testsĮditor-In-Chief: C. Multiple myeloma laboratory tests in the newsīlogs on Multiple myeloma laboratory testsĭirections to Hospitals Treating Multiple myeloma Multiple myeloma laboratory tests On the WebĪmerican Roentgen Ray Society Images of Multiple myeloma laboratory testsĪll Images X-rays Echo and Ultrasound CT Images MRI Natural History, Complications and Prognosis Differentiating Multiple Myeloma from other Diseases
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